The clinical progress of blood purification in treatment of paraquat poisoning
10.3969/J.ISSN.1672-8270.2014.06.026
- VernacularTitle:血液净化治疗百草枯中毒的临床研究进展
- Author:
Guoqiang LI
;
Liang SUN
;
Yuming LI
- Publication Type:Journal Article
- Keywords:
Haemodialysis;
Haemoperfusion;
Paraquat poisoning;
Plasma perfusion;
Blood purification
- From:
China Medical Equipment
2014;(6):79-83
- CountryChina
- Language:Chinese
-
Abstract:
The high mortality of paraquat (PQ) poisonings is mainly due to the lack of effective treatments. The optimal method of extracorporeal removal of paraquat is often a matter of debate. Due to the lack of well-designed studies, we are often left with circumstantial evidence, and we must exercise our best clinical judgment as to whether extracorporeal paraquat removal is beneficial and if so, by what method. It is clear, however, that rapidity in paraquat removal is beneficial. Due to the urgent nature of treatment for paraquat poisoning, there may never be well-designed evidence-based studies to help guide us. In the meantime, we must continue to use less than ideal evidence and our own experience to guide our decision-making process. Most toxicologists recommend rapid initiation of charcoal haemoperfusion (CHP) to lower plasma PQ levels and to limit pulmonary and other organs uptake of PQ.
