Percutaneous renal sympathetic denervation for elderly refractory hypertension patients
10.3969/j.issn.1009-0126.2014.06.010
- VernacularTitle:经皮肾去交感神经术治疗老年难治性高血压患者的临床研究
- Author:
Xiaodong SHENG
;
Xiaoqi JIN
;
Zongcheng ZHU
- Publication Type:Journal Article
- Keywords:
hypertension;
sympathectomy;
glomerular filtration rate;
angiotensin Ⅱ;
aldosterone;
catheter ablation
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2014;(6):592-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficiency ,safety and feasibility of percutaneous renal sympa-thetic denervation (RSD) for elderly refractory hypertension patients .Methods Office and ambu-latory blood pressures ,serum levels of creatinine ,angiotensin Ⅱ and aldosterone ,estimated glo-merular filtration rate (eGFR) and rennin activity were measured in 20 elderly refractory hyper-tension patients before and 1 ,3 ,6 months after percutaneous RSD .Complications of percutaneous RSD were observed .Results The office and ambulatory blood pressures were 16 .9/11 .9 mm Hg (1 mm Hg=0 .133 kPa) ,24 .8/17 .1 mm Hg ,29 .1/20 .5 mmHg and 24 .2/17 .2 mm Hg lower 1 , 3 ,6 months after percutaneous RSD than before percutaneous RSD ( P< 0 .01 ) .No significant difference was found in serum creatinine level and eGFR before and after percutaneous RSD (P>0 .05) .The creatinine ,angiotensin Ⅱand aldosterone levels were significantly lower after percuta-neous RSD than before percutaneous RSD (P<0 .05) .Femoral artery hematoma was detected in 1 patient .Conclusion Percutaneous RSD is a safe ,effective and feasible procedure for elderly re-fractory hypertension patients .
