Impairment of left ventricular function and mechanism analysis after intermittent hypoxia
10.3969/j.issn.1000-4718.2014.06.031
- VernacularTitle:间歇性低氧对左心室功能的损害及机制分析
- Author:
Jinwei WANG
;
Ensheng JI
- Publication Type:Journal Article
- Keywords:
Intermittent hypoxia;
Oxidative stress;
Ventricular remodeling;
Apoptosis
- From:
Chinese Journal of Pathophysiology
2014;(6):1136-1140
- CountryChina
- Language:Chinese
-
Abstract:
Intermittent hypoxia (IH) is a direct consequence of obstructive sleep apnea syndrome (OSAS), which results in left ventricular dysfunction , remodeling and myocardial cell injury .Understanding the mechanisms of OSAS is important for us to prevent and treat the cardiovascular complications in the clinical practices .We summarize the effects of IH on left ventricular function , and analyze the mechanisms at the cellular and molecular levels , including oxidative stress, ion exchangers and inflammation .In addition, the effects of endothelin-1 and hypercapnia on IH-induced cardiac injury are discussed .
