The effects of preoperative level of serum CA19-9 on the prognosis of gastric cancer patients after radical resection
10.3969/j.issn.1000-8179.20140009
- VernacularTitle:术前血清CA19-9水平对胃癌患者生存预后的影响
- Author:
Shupeng ZHANG
;
Han LIANG
;
Jingyu DENG
- Publication Type:Journal Article
- Keywords:
stomach neoplasm;
serum CA19-9;
prognosis
- From:
Chinese Journal of Clinical Oncology
2014;45(11):702-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The influences of detection of the preoperative level of serum CA19-9 were analyzed on the prognosis of gastric cancer patients. Methods:A total of 513 gastric patients with preoperative CA19-9 detection were enrolled and underwent radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital from January 2003 to October 2008. Clinico-pathological variables associated with the CA19-9 level were analyzed, and the prognostic value of CA19-9 was evaluated. Results:Eighty-six (16.8%) patients manifested an increased CA19-9 level, which was associated with ageing, Borrmann typesⅢandⅣ, undifferentiated type, and advanced T stage. The five-year survival rates were 45.7%and 25.6%for patients with normal (<39 U/mL) and significantly high CA 19-9 levels (≥39 U/mL), respectively. Differences in survival rates between the patient groups were statistically significant (P<0.001). Tumor-node-metastasis (TNM)-stratified analysis revealed a difference in overall survival for patients with stageⅢtumors. The significantly increased CA19-9 level was an independent prognostic factor for gastric cancer patients after radical surgery based on multivariate analysis. Conclusion:Detection of preoperative level of serum CA19-9 could provide important information for prognostic evaluation of gastric cancer patients. CA19-9 was a potential independent prognostic factor for gastric cancer patients after surgery.
