VernacularTitle:滤泡细胞性淋巴瘤转化为c-MYC重排的“双击”或“三击”B细胞淋巴瘤3例及文献复习
Author: Le ZHANG ; Xiaoxiao XU ; Shanqi GUO ; Yafei WANG ; Yizhuo ZHANG ; Baocun SUN ; Ling ZHANG
Publication Type:Journal Article
Keywords: double hit; follicular lymphoma; c-MYC gene; fluorescence in situ hybridization; prognosis
From: Chinese Journal of Clinical Oncology 2014;45(11):711-715
CountryChina
Language:Chinese
Abstract: Objective: To analyze the diagnosis and therapy for double-hit lymphoma (DHL) and triple-hit lymphoma (THL). Methods:This study involves three patients with follicular lymphoma (FL) that transformed into DHL or THL. These patients were ad-mitted to our hospital between January 2011 and December 2012. All patients were diagnosed by immunohistochemistry and fluores-cence in situ hybridization (FISH). Results:One FL patient transformed into THL and died after 3 months. The other two FL patients who transformed into DHL and who received R-CHOP and R-ESHAP regimens still failed to achieve complete remission. Conclusion:DHL is a rare type of lymphoma that usually involves the bone marrow and central nervous system. This condition is highly resistant to intensive chemotherapy. Part of the DHL cases result from FL. FISH is important for diagnosis. However, a standard treatment for this type of lymphoma remains lacking.