Effect of Gui-Zhi Fu-Ling Wan on HIF-1α and VEGF in Patients with Endometriosis

VernacularTitle:桂枝茯苓丸对子宫内皮异位症患者内膜组织HIF-1α和VEGF的影响
Author: Rong LIU ; Yue QIN
Publication Type:Journal Article
Keywords: Gui-Zhi Fu-Ling Wan; endometriosis; HIF-1α; VEGF
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(5):1178-1181
CountryChina
Language:Chinese
Abstract: This study was aimed to explore effect of Gui-Zhi Fu-Ling W an (GZFLW) on HIF-1α and vascular en-dothelial growth factor (VEGF) in patients with endometriosis. A total of 68 endometriosis patients in the First Peo-ple's Hospital of Xining from June 2011 to June 2013 were included. All patients received treatment of GZFLW, once a day. After one-month treatment, the treatment efficacy was analyzed. The endometrial tissues (both ectopic endometrium and eutopic endometrium) were obtained before and after treatment. The protein levels of HIF-1α and VEGF as well as the relationship of HIF-1α and VEGF were analyzed by SP immunohistochemistry. The results showed that the total treatment efficacy was 86.76%. Compared with pretreatment, the posttreatment protein levels of HIF-1α and VEGF were significantly reduced (P< 0.05). The decreasing of VEGF protein level and HIF-1α expres-sion level were positively correlated (P< 0.05). It was concluded that GZFLW had better efficacy in the treatment of endometriosis. One of the reasons may be the downregulation of protein levels of HIF-1α and VEGF in endometriosis tissues.