Optimization of Extraction Process of Resveratrol from Polygonum Cuspidatum Based on Central Composite Design and Response Surface Method

VernacularTitle:星点设计-效应面法优化虎杖中白藜芦醇的提取工艺
Author: Lijie WANG ; Jianli LI ; Mingyi SHI ; Yue LUO ; Zixian CHEN
Publication Type:Journal Article
Keywords: Polygonum cuspidatum; resveratrol; extraction process; central composite design; response surface method
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(5):1193-1200
CountryChina
Language:Chinese
Abstract: This study was aimed to optimize the extraction process of resveratrol by central composite design (CCD) and response surface method (RSM), based on the result of single factor experiment. Resveratrol was extracted from Polygonum cuspidatum by water bath extraction of organic solvent. And content of resveratrol was taken as index in the investigation of solvent concentration effect, extraction time and solvent content on extraction process. The results showed that the optimum condition was 12.7 times amount of 72.0% ethanol and extract for 2 times under the temperature of 50℃, 1.1 h for each time; the average deviation between the maximum theoretical value and measured value was 0.83%. It was concluded that this extraction process was highly predictive, which provided experimental evidence for the industrial production of P. cuspidatum extraction.