Relation between IL-8 gene polymorphism and delayed Alzheimer's disease in Xinjiang Han people
10.3969/j.issn.1009-0126.2014.06.017
- VernacularTitle:白细胞介素8基因多态性与新疆汉族迟发型阿尔茨海默病关系的研究
- Author:
Mei LIU
;
Ying WANG
;
Feiyan HE
- Publication Type:Journal Article
- Keywords:
interleukin-8;
Alzheimer disease;
genotype;
alleles;
genetic predisposition to disease
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2014;(6):617-619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between IL-8 gene-251A/T polymorphism and delayed Alzheimer's disease (AD)in Xinjiang Han people .Methods Eighty delayed AD patients served as a delayed AD group and 80 subjects undergoing physical examination served as a control group in this study .Distribution of IL-8 gene-251A/T polymorphism in two groups was detected by PCR-RFLP .Results The distribution of genotypes and alleles was different in two groups (P=0 .023 , P= 0 .010) .Further stratified analysis showed that the frequency of A allele was significantly higher in delayed AD group than in control group (OR= 1 .851 ,95% CI:1 .159 -2 .957 ,P=0.010) ,indicating that A allele is the risk factor for delayed AD .The frequency of AA genotype was significantly higher in delayed AD group than in control group (OR=3 .370 ,95% CI:1 .143-9.939 ,P=0 .023) ,indicating that the risk of delayed AD was 3 .370-fold higher in subjects with AA genotype than in those with TT genotype .The AT genotype was not related with the risk of delayed AD (OR=1 .944 ,95% CI:0 .994-3 .803 ,P=0 .051) .Conclusion IL-8 gene-251A/T pol-ymorphism is related with the risk of delayed AD .
