Role of immunoglobulin in treating chronic obstructive pulmonary disease with fungal infection

VernacularTitle:丙种球蛋白在治疗慢性阻塞性肺疾病合并真菌感染中的作用
Author: Jianrong ZHU ; Xiaolian WAN
Publication Type:Journal Article
Keywords: immunoglobulin; chronic obstructive pulmonary disease; fungal infection; anti-infective therapy
From: Chinese Journal of Infection Control 2014;(5):281-283
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical effect of intravenous immunoglobulin(IVIG)on chronic obstructive pulmonary disease(COPD)and fungal infection.Methods Seventy-two COPD patients with fungal infection were randomly and equally divided into conventional and intervention group.Patients in conventional group were treated with common schedule for COPD plus antifungal agents;patients in intervention group received 1 0 g/d IVIG besides routine therapy.Length of hospital stay and prognosis were recorded,and therapeutic effectiveness were evaluated. Results The effectiveness rate of intervention group was significantly higher than that of conventional group ([88.89%,32/36]vs [66.67%,24/36]);the average length of hospital stay was significantly shorter than conven-tional group ([12.62±7.51]d vs [20.81±6.92]d),and mortality was lower than conventional group ([5.56%, 2/36]vs [22.22%,8/36]),the differences were statistically significant (P<0.05).Conclusion IVIG for treating COPD with invasive pulmonary fungal infection can improve therapeutic efficacy,shorten length of hospital stay and decrease mortality rate.