Advances of mechanism of habenula in reward and its role in mental illness
10.3867/j.issn.1000-3002.2014.03.023
- VernacularTitle:缰核在中枢奖赏调控的机制及其在精神疾病中的作用研究进展
- Author:
Shujun YANG
;
Yin ZHANG
;
Fuqiang ZHANG
- Publication Type:Journal Article
- Keywords:
habenula;
psychotic disorders;
schizophrenia;
depression;
drug habituation
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(3):443-448
- CountryChina
- Language:Chinese
-
Abstract:
The habenula complex,an ancient and conservative nucleus during biological evolution, is involved in many i mportant biological functions,such as maternal behavior,pain,sleep,learning and reward.As an important node in the dopamine reward network,its functions(including the maintenance of individual survival while avoiding disadvantages)and mechanis m in the reward process have attracted wide attention.The dysfunction of habenula is closely related to many psychotic disorders,such as de-pression,schizophrenia and drug habituation.Habenula may also become a potential target for clinical treatment of these mental illnesses.So clarifying the role and neurobiological mechanisms of habenula in the central nervous system is of great theoretical and clinical value.
