Progress of inhibitory effect of medicinal plant extracts on calcineurin
10.3867/j.issn.1000-3002.2014.03.026
- VernacularTitle:药用植物提取物抑制钙调磷酸酶活性作用的研究进展
- Author:
Na HE
;
Pengfei WU
;
Zhifeng CUI
- Publication Type:Journal Article
- Keywords:
plants,medicinal;
calcineurin;
calcineurin inhibitor
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(3):462-467
- CountryChina
- Language:Chinese
-
Abstract:
Calcineurin inhibitors,such as cyclosporin A and tacroli mus,are widely-used i mmuno-suppressive drugs clinically.However,renal toxicity,hyperglycae mia and other side-effects can occur over long-term use.Isolation of novel calcineurin inhibitors fro m medicinal plants in recent years has pro-vided a new approach to the development of new immunosuppressive drugs with high efficiency and low toxicity.Recnt studies have shown that medicinal plant extracts, such as isogarcinol, quercetin, kae mpferol,phenylethanoid glycosides,ere mophilane sesquiterpenes A and B,pisiferdiol,as well as extracts fro m Smilax china L and Jasminum humile L,have obvious inhibitory effect on calcineurin.
