Role of HOX genes in tumor genesis and development
10.3969/j.issn.0529-1356.2014.03.025
- VernacularTitle:HOX 基因在肿瘤发生发展过程中的作用
- Author:
Miaomiao NIU
;
Jun ZHAN
;
Hongquan ZHANG
- Publication Type:Journal Article
- Keywords:
HOX gene;
Transcription factor;
Tumor;
Biological regulation;
Immunohistochemistry
- From:
Acta Anatomica Sinica
2014;(3):430-436
- CountryChina
- Language:Chinese
-
Abstract:
HOX gene belongs to a highly conserved subgroup of the homeobox superfamily .The HOX genes constitute a family of transcription factors that play key roles in embryonic development , regulating numerous processes , such us cellular growth, differentiation, apoptosis, motility and angiogenesis.The present review shows that there is a close relationship between aberrant expression of HOX genes and malignancy .This article summarizes briofly the advances in the research on HOX genes and their roles in tumor genesis .
