Role of procalcitonin in early diagnosis of hand,foot and mouth disease with bacterial infection
10.3969/j.issn.1671-9638.2014.05.006
- VernacularTitle:降钙素原在手足口病合并细菌感染患儿中的早期临床诊断作用
- Author:
Jinling YANG
;
Longfeng CHEN
;
Xiaofeng QIN
- Publication Type:Journal Article
- Keywords:
hand,foot and mouth disease;
enterovirus 71;
coxsachievirus A16;
child;
epidemiology;
procalcitonin;
bacterial infection
- From:
Chinese Journal of Infection Control
2014;(5):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of procalcitonin (PCT)in the early diagnosis for hand,foot and mouth disease (HFMD)with bacterial infection.Methods Clinical data of 234 HFMD children who were hospitalized be-tween January and July 2012 were analyzed retrospectively,according to discharge diagnosis,data were divided into simple viral infection group (n=178)and viral associated with bacterial infection group (n=56),and data of 20 healthy children were selected as the control group.Serum PCT,C-reactive protein (CRP)and peripheral white blood cell (WBC)count were compared.Results There was significant difference in the level of PCT,CRP and WBC among three groups (F=381.94,24.18,and 26.46,respectively,all P<0.05).The positive rate of PCT,CRP and WBC among three groups was significantly different(χ2=178.25,38.98,and 71.21,all P<0.05),PCT,CRP and WBC in bacterial infection group(92.86%[52/56],85.71%[48/56],and 87.50%[49/56]respectively)were significantly higher than those of simple viral infection group (3.93%[7/178],62.36%[111/178],and 30.90%[55/178]respectively)and healthy control group (5.00%[1/20],10.00%[2/20],and 5.00%[1/20]respectively).The sensitivity rate of PCT,CRP and WBC was 92.86%,85.71%,and 87.50% respectively,specificity rate was 95.00%,90.00%,and 95.00% respectively.Conclusion The level of PCT has important value for the early diagno-sis of HFMD with bacterial infection,and its accuracy rate and sensitivity are better than CRP and WBC levels.
