Advance of molecular imaging in evaluation of RNA interference
10.3760/cma.j.issn.2095-2848.2014.03.026
- VernacularTitle:分子成像技术在监测RNA干扰治疗中的研究进展
- Author:
Yan LIN
;
Zhiyi CHEN
;
Feng YANG
- Publication Type:Journal Article
- Keywords:
RNA interference;
Optical imaging;
Radionuclide imaging;
Magnetic resonance imaging;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(3):250-253
- CountryChina
- Language:Chinese
-
Abstract:
Due to its effectiveness and specificity,RNA interference (RNAi) technology is widely used in the treatment of tumor,viral infectious and metabolic diseases.Noninvasively tracing the delivery of therapeutic RNA molecules in vivo and evaluating the therapeutic effects are important to promote the clinical application of RNAi technology.Molecular imaging allows noninvasive visualization of biological processes at the cellular and molecular level in vivo.It can be used to monitor the biodistribution of therapeutic RNA molecules and to assess the effects of the RNAi.This article reviews the advance of molecular imaging in monitoring the delivery of RNAi molecules and evaluating the therapeutic effects of RNAi.
