Correlation between patient's age and expression of Ki-67 or microvessel density in the tissues of human hepatocellular carcinoma
10.3760/cma.j.issn.1006-9801.2014.05.009
- VernacularTitle:肝癌组织中Ki-67表达水平及微血管密度与患者年龄的相关性
- Author:
Min LUO
;
Ying CAO
;
Anzhi WEN
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Ki-67 antigen;
Microvessel density;
Correlation analysis
- From:
Cancer Research and Clinic
2014;26(5):322-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between patient' s age and expression of Ki-67 or microvessel density in primary hepatocellular carcinoma.Methods The expression level of Ki-67 and the microvessel density in the hepatocellular carcinoma tissues were detected by immunohistochemical method,and the correlation between age and expression of Ki-67 or microvessel density were analyzed.Results In 48 cases of hepatocellular carcinoma tissues,Ki-67 expressed to varying degrees,but the positive rate was 83.3 ％ (40/45),and there was no expression in corresponding noncancerous tissues (P ＜ 0.01).Microvessel density marked by CD34 in cancer tissues and noncancerous tissues were 32.17±8.06 and 10.83±2.85 respectively.Microvessel density of cancer tissues was higher than noncancerous tissues (P ＜ 0.01).Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma were negatively correlated with the age (r =-0.418,P =0.003 and r =-0.443,P =0.002 respectively).Conclusion Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma are negatively correlated with patient' s age,which may suggest worse prognosis for the younger patients.
