Clinical significance of expression of p73 gene and its protein in nasopharyngeal carcinoma
10.3760/cma.j.issn.1006-9801.2014.05.008
- VernacularTitle:p73基因及其蛋白在鼻咽癌中表达的临床意义
- Author:
Haiqing LUO
;
Donghong YANG
;
Zhonghua YU
;
Xiangyong LI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Gene,p73;
Protein
- From:
Cancer Research and Clinic
2014;26(5):318-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of p73 gene and its protein and their relation with clinicopathologic features in nasopharyngeal carcinoma (NPC) tissues.Methods Expression of p73 mRNA and protein in 52 NPC and 25 normal nasopharyngeal tissues was detected by real-time fluorescent quantitative PCR and immunohistochemistry.Results Expression of p73 mRNA and protein was significantly higher in NPC than that in normal nasopharyngeal tissues (mRNA:73.1％ vs 24.0 ％,protein:71.2 ％ vs 36.0 ％),there were significant statistical differences between the two groups (P ＜ 0.05),and their expression was closely related to tumor invasion depth,degree of differentiation and clinical stage (P ＜ 0.05).Expression of p73 gene and protein was not closely related to age and gender (P ＞ 0.05).Conclusion Detection expression of p73 mRNA and its protein can be helpful in the diagnosis and prognostic evaluation in NPC.
