Effects of different bladder infusion rates on bladder responses in healthy and complete spinal cord injury rats
10.3760/cma.j.issn.0254-1424.2014.05.001
- VernacularTitle:脊髓损伤大鼠和健康大鼠对不同速率膀胱灌注响应的研究
- Author:
Ping SHI
;
Hongliu YU
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
Bladder infusion;
Bladder response
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2014;36(5):321-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the bladder responses to different rates of bladder infusion in healthy and spinal cord injured rats.Methods Fourteen adult female Sprague-Dawley rats were used and divided into two groups:healthy group (n =7) and spinal transection injury group (n =7).The intravesical pressures induced by continuous infusion of saline with different rates under general anesthesia were recorded and compared between the two groups.Results In healthy group the responses of bladder contraction were dependent upon the rate of bladder infusion,and contraction time became shorter while increasing the infusion rate (P ＜ 0.05),i.e.contraction time was (401.0±132.4),(215.7 ±95.9),(108.3 ±59.1) and (52.5 ±32.8)s,respectively,when the infusion rate was 0.05,0.1,0.2 and 0.5 mL/min.Compared with healthy group,spinal transection injury group had significantly shorter bladder contraction time (P ＜ 0.05),however the relationship between bladder contraction time and infusion rate was much weakened.Spinal transaction injury rats had significantly lower peak of bladder pressure (P ＜ 0.05) compared with healthy rats.There was no significant difference for contraction durations between the two groups.Conclusions The infusion rates influenced the contraction periods for both healthy and spinal cord injured rats.During bladder infusions with a same rate,the contraction time and the peak of bladder pressure were determined by bladder conditions,i.e.healthy or neurogenic with spinal cord injury.
