Event-related potential P300 in patients with obstructive sleep apnea hypopnea syndrome and its influencing factors
10.3760/cma.j.issn.0254-1424.2014.05.006
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者事件相关电位P300及其影响因素分析
- Author:
Zhengjun XIAO
;
Hui ZHU
;
Maojun GAO
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea hypopnea syndrome;
Event-related potential;
Cognitive function
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2014;36(5):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics and influencing factors of event-related potential (ERP) P300 in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods Twenty-two OSAHS patients (OSAHS group) and 18 healthy subjects (control group) were recruited,and the ERP P300 was recorded with all the subjects.The correlation between latency and amplitude of P300 and influencing factors including variation of sleep mode,apnea hypopnea index (AHI),mean oxyhemoglobin saturation level(MSaO2),the lowest of oxyhemoglobin saturation level (LSaO2),time of non-rapid eye movement (NREM) sleep Ⅰ,Ⅱ,Ⅲ,Ⅳ stage and rapid eye movement (REM) sleep over total sleep time and total sleep time of SaO2 ＜ 90％ (90％ SaO2) were analyzed by using linear regression correlation analysis and multiple stepwise regression analysis.Results The latencies of P3 component of P300 in OSAHS group were longer than that of control group[(344.24 ± 23.99)ms versus (311.17 ± 15.65) ms] (P＜ 0.05),while the amplitudes were decreased and lower in OSAHS group than that in control group [(3.66 ± 1.49) μV versus (6.26 ± 1.48) μV] (P ＜ 0.05).There revealed positive correlations between P3 latency and NREM Ⅰ and Ⅱ (r=0.492,P＜0.05),90％SaO2(r=0.627,P＜0.01),AHI(r=0.882,P＜0.01); negative correlation between P3 latency and NREM Ⅲ and Ⅳ (r =-0.558,P ＜ 0.01),LSaO2,(r =-0.479,P ＜0.05),MSaO2 (r =-0.519,P ＜ 0.05) was shown.There also revealed negative correlation between P3 amplitude and NREM Ⅰ and Ⅱ (r=-0.491,P ＜0.05),90％SaO2(r =-0.626,P＜0.01),AHI(r =-0.866,P ＜0.01),and positive correlation between P3 amplitude and NREM Ⅲ and Ⅳ (r =0.516,P ＜ 0.05),LSaO2 (r =0.475,P ＜ 0.05) 、MSaO2 (r =0.514,P ＜ 0.05).Stepwise regression and multivariate analysis revealed that AHI was one of the most significant influencing factors for latency and amplitude of P300 (P ＜ 0.01).Conclusion The OSAHS patients have cognitive dysfunction as reflected by the abnormalities of event-related potential P300 and the scale of its changes are correlated with the severity of OSAHS.The AHI is the most influential factor of P300.
