Recurrence of Colorectal Neoplasm Cannot Be Predicted by Sonic Hedgehog Expression in the Normal Colonic Tissue.
- Author:
Ji Young LEE
1
;
Sun Young LEE
;
Hye Seung HAN
;
So Young KIM
;
Sung Noh HONG
;
Jeong Hwan KIM
;
In Kyung SUNG
;
Hyung Seok PARK
;
Chan Sup SHIM
;
Choon Jo JIN
Author Information
- Publication Type:Original Article
- Keywords: Hedgehogs; Colorectal neoplasms; Recurrence
- MeSH: Colon; Colonic Neoplasms; Colonoscopy; Colorectal Neoplasms; Follow-Up Studies; Hedgehogs; Humans; Mucous Membrane; Recurrence
- From:Intestinal Research 2012;10(3):265-271
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The expression of sonic hedgehog (Shh) in the colon cancer cell has been implicated in colorectal carcinogenesis. However, the association between Shh expression in the normal colonic mucosa and the recurrence of colorectal neoplasm after tumor resection has not been well documented. The aim of the study was to determine the association between Shh expression in the normal colonic mucosa and in the recurrence of colorectal neoplasm. METHODS: Fifty-five patients who underwent a long-term follow-up colonoscopy after the colorectal neoplasm resection were included. At the time of the tumor resection, Shh expression in the normal colonic mucosa was examined. The association between Shh expression in the normal colonic mucosa and the recurrence of colorectal neoplasm was analyzed. RESULTS: In total, 97 colorectal neoplasms were detected among 41 subjects after a mean follow-up period of 63 weeks (range 27-254 weeks). Of 55 subjects, 26 (47.3%) exhibited positive Shh expression in the normal colonic tissue, and the recurrence rate did not differ with the degree of Shh expression (P=0.238). The degree of Shh expression was not associated with the number (P=0.389), size (P=0.928), location (P=0.410), pathologic types (P=0.127), or time of recurrence (P=0.711) of the recurred colorectal neoplasm. CONCLUSIONS: Most colorectal neoplasm patients show recurrence after the resection and exhibit Shh expression in the normal colonic tissue. The degree of Shh expression in the normal colonic mucosa does not predict the recurrence of colorectal neoplasm.
