Dynamic monitoring of donor specific antibodies in living-relative renal transplantation and early intervention
10.3760/cma.j.issn.0254-1785.2014.05.003
- VernacularTitle:活体肾移植受者体内供者特异性抗体的动态监测及早期干预治疗
- Author:
Yu CHEN
;
Jiangyan LI
;
Xiaoyan LOU
;
Hao WANG
;
Lei ZHANG
;
Youhua ZHU
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Living donors;
Antibody specificity
- From:
Chinese Journal of Organ Transplantation
2014;35(5):267-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical application of HLA donor specific antibodies (DSAs) detected by Luminex single antigen beads,and to discuss the impact of early intervention on renal function.Method In 64 cases of living-relative renal transplantation,DSA was detected using a Luminex single antigen assay before and after transplantation.The positive recipients were given large doses of intravenous irnmunoglobulin (IVIG) and increased doses of mycophenolate mofetil (MMF).The relationship between DSA and renal function was analyzed.Result DSA was negative in all recipients before transplantation.Ten cases of DSA positive recipients were found in HLA mismatch after transplantation.After the intervention,two cases of DSA positive recipients became negative,immunofluorescence intensity was decreased by more than 50％ in 6 cases,and no significant reduction was found in the other two cases.Antibody-mediated rejection (AMR) occurred in two cases of intervention ineffective recipients after 3 to 6 months and the renal function was impaired.Conclusion Dynamic monitoring of DSA using Luminex single antigen beads may timely predict changes of renal function.Early application of large doses of IVIG and increasing doses of MMF can reduce the incidence of AMR.
