Protection of aorta from atherosclerosis in diabetic rats with TRAIL
10.3760/cma.j.issn.1000-6699.2014.06.018
- VernacularTitle:TRAIL对糖尿病大鼠主动脉的保护作用
- Author:
Min LIU
;
Guangda XIANG
;
Junyan LU
;
Jing DONG
;
Lin XIANG
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-related apoptosis ligand;
Diabetic mellitus,experimental;
Atherosclerosis
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(6):519-522
- CountryChina
- Language:Chinese
-
Abstract:
Four-week-old male Sprague-Dawley rats were rendered diabetic by intraperitoneal injection of streptozotocin (STZ) after feeding high-fat-diet for 8 weeks,and divided into diabetes group and tumor necrosis factorrelated apoptosis ligand(TRAIL) group.Normal rats severed as a control group.Treatment with TRAIL lasted for 3 months.Total cholesterol,triglycerides,low-density lipoprotein-cholesterol,blood glucose,and insulin levels were decreased in TRAIL group,as compared with diabetes group.Area of atherosclerotic lesion in TRAIL group [(23.8 ± 5.7) ％] was significantly smaller than that in diabetes group [(47.6 ± 7.8) ％].It suggested that TRAIL may reduce the area of atherosclerotic lesion in diabetic rats.
