Clinical value of triptorelin stimulation test in differential diagnosis of disorder due to delayed puberty: 128 cases report

VernacularTitle:曲普瑞林兴奋试验对青春发育延迟的诊断意义:128例报告
Author: Yanxia DING ; Zhizhen LI ; Qingzhu WANG ; Hui RAN ; Ziyi XIE ; Guijun QIN
Publication Type:Journal Article
Keywords: Idiopathic hypogonadotropic hypogonadism; Constitutional delayed puberty; Triptorelin stimulation test; LH
From: Chinese Journal of Endocrinology and Metabolism 2014;30(6):482-485
CountryChina
Language:Chinese
Abstract: Objective To evaluate the diagnostic value of triptorelin stimulation test in disorders due to delayed puberty.Methods Triptorelin stimulation test was carried out in 128 teenagers with delayed puberty,due to idiopathic hypogonadotropic hypogonadism(IHH) in 77 cases and constitutional delayed puberty(CDP) in 51.Blood samples were obtained 15 min before and 0,30,60,and 120 min after tripotorelin administration,and the levels of LH and FSH were determined.An extended GnRH stimulation test was carried out in 3 patients with IHH.Results Peak LH,peak FSH,and LH increment were parameters with high diagnostic value.A cut-off point at 8.2 IU/L of peak LH showed a sensitivity of 87％ and a specificity of 80.4％ in the differential diagnosis of IHH and CDP.Conclusion Peak LH cut-off point at 8.2 IU/L of triptorelin stimulation test seems to be sufficient to confirm diagnosis of IHH and CDP.An extended GnRH stimulation test may distinguish hypothalamic from the pituitary hypogonadotropic hypogonadism.