Advances in pathogenesis and management of hepatitis C virus-related thyroid dysfunction
10.3760/cma.j.issn.1674-2397.2014.03.023
- VernacularTitle:丙型肝炎病毒相关甲状腺功能障碍发病机制与临床治疗研究进展
- Author:
Yazhou LIU
;
Qinghua MENG
- Publication Type:Journal Article
- Keywords:
Hepatitis C;
Thyroid diseases;
Interferons;
Autoimmunity
- From:
Chinese Journal of Clinical Infectious Diseases
2014;7(3):271-276
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis C virus (HCV)-related thyroid dysfunction is a common complication in patients with chronic hepatitis C,including Graves' disease,Hashimoto thyroiditis,destructive subacute thyroiditis,hyperparathyroidism or hypothyroidism,with or without abnormal autoantibodies or thyroidrelated antibodies.The possible pathogenesis of HCV-related thyroid dysfunction includes bystander activation,molecular mimicry,effects of interferon and susceptibility associated with genetic polymorphism on particular locus.By now,there is still no criteria for diagnosis and treatment of HCV-related thyroid dysfunction.For patients with mild HCV-related thyroid dysfunction,observation may be appropriate; and for those with serious symptoms,anti-thyroid drug,levothyrocine,surgery or symptomatic treatment may be applied according to clinical symptoms.This paper gives an overview of the prevalence,clinical characteristics and possible pathogenesis of HCV-related thyroid dysfunction.
