Research progress on HBx gene in pathogenesis of hepatitis B virus-associated glomerulonephritis
10.3760/cma.j.issn.1674-2397.2014.03.024
- VernacularTitle:HBx基因在乙型肝炎病毒相关性肾炎致病机制中的研究进展
- Author:
Wei JIANG
;
Hui DONG
;
Ruixia MA
;
Guangju GUAN
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Hepatitis B virus X gene;
Pathogenesis
- From:
Chinese Journal of Clinical Infectious Diseases
2014;7(3):277-281
- CountryChina
- Language:Chinese
-
Abstract:
HBx gene is a multifunctional regulator,which has extensive trans-activating effects,and can activate transcription factors,inhibit DNA repair and regulate cell proliferation,differentiation and apoptosis.In recent years,the role of HBx gene in pathogenesis of hepatitis B virus-associated glomemlonephritis (HBV-GN) has been extensively studied,and the results show that HBx can promote glomerular mesangial cell proliferation,and induce damage or apoptosis of podocytes and renal tubular epithelial cells.This paper reviews the research progress on biological characteristics of HBx and its role in pathogenesis of HBV-GN.
