Recurrent Acute Pericarditis Induced by 5-aminosalicylates in a Patient with Inflammatory Bowel Disease.
- Author:
A Ra CHOI
1
;
Mi Na KIM
;
Ji Hoon LEE
;
Yong Kang LEE
;
Yoon Hea PARK
;
Hye Sun SHIN
;
Tak Geun OH
;
Hee Jin PARK
;
Min Suk PARK
;
Seungtaek LIM
;
Soo Jung PARK
;
Sung Pil HONG
;
Tae Il KIM
;
Won Ho KIM
;
Jae Hee CHEON
Author Information
- Publication Type:Case Report
- Keywords: Crohn Disease; Colitis, Ulcerative; Mesalamine; Pericarditis
- MeSH: Anti-Inflammatory Agents; Chest Pain; Colitis, Ulcerative; Crohn Disease; Echocardiography; Exanthema; Fever; Humans; Immunologic Factors; Inflammation; Inflammatory Bowel Diseases; Intestines; Leukopenia; Male; Mesalamine; Nausea; Nephrotic Syndrome; Pericarditis; Pneumonia; Sulfasalazine; Sweat; Sweating; Thorax; Thrombocytopenia; Vomiting; Young Adult
- From:Intestinal Research 2012;10(3):289-294
- CountryRepublic of Korea
- Language:Korean
- Abstract: Inflammatory bowel disease (IBD) is an idiopathic chronic inflammation of the intestines. IBD treatment may require anti-inflammatory agents such as sulfasalazine or 5-aminosalicylate (5-ASA) and immunomodulators to control the symptoms. However, these agents have a variety of common adverse effects such as nausea, vomiting, skin rash, leukopenia, thrombocytopenia, and infections. Moreover, rare side effects such as nephrotic syndrome, pneumonitis, and pericarditis can occur. A 21-year-old male was admitted to the hospital due to acute chest pain, fever, and sweating. The patient had a history of Crohn's disease and had been taking mesalazine for 3 weeks. Chest x-ray, echocardiography, and clinical manifestations revealed that the patient had acute pericarditis. However, we did not recognize the relationship between these findings and 5-ASA at that time. Two years later, the patient took 5-ASA again, and similar symptoms occurred, which led us to confirm that he suffered from pericarditis induced by this drug. We report a case of acute recurrent pericarditis that developed after taking 5-ASA for IBD treatment with a review of the literature.
