The association of the SNP in miRNA146a with genetic prediposion and the earlier recurrence after resection for hepatocellular carcinoma

VernacularTitle:microRNA146a的单核苷酸多态性与肝细胞性肝癌易感性和切除术后早期复发的关系
Author: Zheng ZHOU ; Dinghua YANG
Publication Type:Journal Article
Keywords: Hepatocellular carcinoma; microRNA; Genetic prediposion; Recurrence
From: Chinese Journal of Hepatobiliary Surgery 2014;20(5):338-341
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of the SNP in miRNA146A with genetic prediposion and earlier recurrence after resection for hepatocellular carcinoma (HCC).Methods In the casecontrol study including 173 HCC cases,DNA were exacted from cancer tissue embedded with paraffin and were amplificated by PCR,SNP was explored in gene sequence of miRNA146a (385 base pair including extron).The outcome were analyzed with genetic prediposion and clinical features.Result Only hsa-mir-146a rs2910164 was found.The genetype frequence of C/C 、G/G and C/G at rs2910164 gene locus were separately 61 (35.3％),21 (15％) and 86(49.7％) in cases.Compared to G/G genetype,C/C and C/G genetype were danger factor to onset risk of HCC (OR =3.086,95％ CI:1.289-7.390) ; C/G was danger factor to earlier recurrence after resection(OR =8.179,95％ CI:2.248-29.759).Conclusion rs2910164 may be associated with genetic prediposion and earlier recurrence after resection of HCC in Jiangxi hans