The research progress on machine perfusion preservation of livers
10.3760/cma.j.issn.1007-8118.2014.05.020
- VernacularTitle:机械灌注保存肝脏的研究进展
- Author:
Xiaojun SUI
;
Zhijun ZHU
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Marginal livers;
Machine perfusion
- From:
Chinese Journal of Hepatobiliary Surgery
2014;20(5):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is currently the only treatment option for end-stage liver disease,but it is limited by the lack of high quality donor livers.The ongoing liver donor shortage could be alleviated by the consequent expansion of do-nor criteria to include the use of livers that would once have been discarded as unsuitable,marginal livers.Static cold storage,the current gold standard of organ preservation,is incapable of reversing the ischemic damage these organs have sustained.In hepatic transplantation,the limitations of cold storage are reflected in the significantly higher rates of early al]ograft dysfunction,primary non-function,and local ischemic cholangiopathy,especially seen with older,steatotic and donation after cardiac death (DCD) grafts.The existing cold storage technology has restricted the use of this kind of organs and machine perfusion preservation technology becomes an alternative choice.In this paper,we review the research progress on machine perfusion preservation of livers,and introduce the normothermic machine perfusion.
