Evaluation of genechip for detecting isoniazid- and rifampicin-resistance of Mycobacterium tuberculosis in China: a Meta-analysis
10.3760/cma.j.issn.1000-6680.2014.06.010
- VernacularTitle:中国开展基因芯片检测结核分枝杆菌对异烟肼和利福平耐药性的Meta分析
- Author:
Hong GENG
;
Yongwen LI
;
Xinxu LI
;
Zhiping WANG
;
Wuwei TAO
;
Chunbao YU
- Publication Type:Journal Article
- Keywords:
Mycobacterium tuberculosis;
Tuberculosis;
Oligonucleotide array sequence analysis;
Meta-analysis
- From:
Chinese Journal of Infectious Diseases
2014;32(6):357-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of genechip in detecting isoniazid-and rifampicinresistance of Mycobacterium tuberculosis (MTB) in China.Methods Studies of genechip in detecting MTB resistance to isoniazid and rifampicin in China,which were published from January 1995 to June 2013,were identified through searches of PubMed,Science Direct,CBMDISC,CNKI and Wanfang database.Meta-Disc1.4 software was used for all analyses.Results Totally 618 articles were identified.Fifteen articles published from 2004 to 2013 were finally included in the study.The pooled sensitivity and specificity of genechip in detecting MTB resistance to isoniazid was 0.79 (95 ％CI:0.77-0.81) and 0.94 (95％CI:0.93-0.95),respectively,with the area under curve (AUC) of 0.86.The pooled sensitivity and specificity of genechip in detecting MTB resistance to rifampin was 0.91 (95％CI:0.89-0.92) and 0.96 (95％CI:0.96-0.97),respectively,with the AUC of 0.97.The pooled sensitivity and specificity of genechip in detecting MTB resistance to multidrug was 0.75 (95％CI:0.72-0.78) and 0.97 (95％ CI:0.96-0.98),respectively.Conclusions The effect of genechip in detecting MTB resistance is moderate for isoniazid,while better for rifampin in China.More studies are needed to evaluate the effect of genechip in detecting multidrug resistance in MTB.
