Clinical significance of retinal binding protein and cystatin C in blood and urine of patients with chronic kidney disease
10.3760/cma.j.issn.1008-6315.2014.05.005
- VernacularTitle:慢性肾脏病患者血、尿视黄醇结合蛋白和血、尿胱抑素C的表达及其临床意义
- Author:
Hong LIU
;
Chen LU
;
Ying LIU
;
Kai LIU
;
Hua YUE
;
Hong JIANG
- Publication Type:Journal Article
- Keywords:
Urine Cystatin C;
Urine retinal binding protein;
Blood cystatin C;
Blood retinal binding protein;
Chronic kidney disease
- From:
Clinical Medicine of China
2014;30(5):464-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of retinal binding protein (RBP) and Cystatin C in blood and urine in patients with chronic kidney disease (CKD).Methods One hundred and twenty-one patients with CKD in Nephrology Laboratory of The People's Hospital of Xinjiang Uygur Autonomous Region from Aug.2012 to Jan.2013 were served as the case group.Sixty healthy check-up people were considered as control group.Enzyme linked immunosorbent assay was used to detect RBP and Cystatin C in urine,and the immune turbidimetry testing was applied to detect RBP and Cystatin C in blood.The receiveroperating characteristic (ROC) curve and area under curve (AUC) were applied to evaluate the sensibility and diagnostic value of indexes in CKD.Results The positive rate of RBP,Cystatin C in urine and blood were 89.6％,92.6％,52.5％,59.5％ respectively of 12 patients in case group,higher than those in control group (all value were 0,P ＜0.001).ROC curve showed that the sensitivity of urine RBP and Cystatin C were higher than that in blood of case group.AUC of RBP,Cystatin C level in urine and blood were 0.915,0.974,.655,and 0.623 respectively.And 95％ confidence interval were 0.877-0.954,0.956-0.992,0.575-0.736,0.543-0.702 respectively,and the differences are statistically significant (P ＜ 0.001).Conclusion The sensitivity of urine cystatin C and RBP are significantly higher than that in blood,which might be served as a diagnostic marker of CKD and can provide important basis for clinical diagnosis.
