Meta-analysis of effect of pulmonary surfactant on acute lung injury
10.3760/cma.j.issn.1008-6315.2013.13.007
- VernacularTitle:外源性肺表面活性物质对成人急性肺损伤影响的Meta分析
- Author:
Ying JIN
;
Jian XU
;
Yan ZHONG
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Acute respiratory distress syndrome;
Pulmonary surfactant;
Meta-analysis
- From:
Clinical Medicine of China
2013;29(z1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of pulmonary surfactant on acute lung injury.Methods The randomized controlled study involving pulmonary surfactant on acute lung injury were identified from Cochrane Library,PubMed,China Academic Journals Full-text database,Chinese Biomedical Literature Database and Chinese Journal Full-text database.According to inclusion and exclusion criteria,the quality of papers were evaluated and then extract the valid data for meta-analysis.Results The current study included 5 English papers,including 1219 cases of patients.Meta analysis showed that:(1) There was no significant difference between experimental group and control group in term of mechanical ventilation(WMD =-1.08,95％ CI(-3.00,0.85),P =0.27).(2) Two studies conducted the ICU time comparison and there was no difference in experimental group and control group(WMD =-0.61,95％CI(-4.63-3.41),P =0.77).(3) Three studies were conducted the survival rates and no difference had found regarding of survival rates between experimental and control group (RR =1.41,95 ％ CI(0.94-2.11),P =0.10).Conclusion The existing clinical evidences showed the addition of pulmonary surfactant have no significant effect regarding of mechanical ventilation time,ICU length of stay and survival rate in patients with acute lung injury compared with conventional therapy However,due to the quality and the limitations of the studies and selection bias and measurement bias,it was needed more high-quality,large-scale randomized controlled clinical studies to validate.
