Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats.
10.5625/lar.2011.27.4.301
- Author:
So Young CHOI
1
;
Dongsun PARK
;
Goeun YANG
;
Sun Hee LEE
;
Dae Kwon BAE
;
Seock Yeon HWANG
;
Paul K LEE
;
Yun Bae KIM
;
Ill Hwa KIM
;
Hyun Gu KANG
Author Information
1. College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Korea. kang6467@cbu.ac.kr
- Publication Type:Original Article
- Keywords:
Osteoporosis;
bone mineral density;
Sigma Anti-bonding Molecule Calcium Carbonate;
17beta-estradiol;
osteocalcin;
type I collagen C-terminal telopeptides
- MeSH:
Animals;
Bone Density;
Calcium;
Calcium Carbonate;
Collagen Type I;
Drinking;
Drinking Water;
Female;
Femur;
Humans;
Minerals;
Organ Size;
Osteocalcin;
Osteoporosis;
Osteoporosis, Postmenopausal;
Phosphorus;
Rats;
Rats, Sprague-Dawley;
Weights and Measures
- From:Laboratory Animal Research
2011;27(4):301-307
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17beta-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17beta-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.
