Expression of placenta heat shock protein-90 in patients with hypertensive disorders complicating pregnancy

VernacularTitle:热休克蛋白90在妊娠期高血压疾病患者胎盘组织中的表达
Author: Mei YU ; Xueqin LIU ; Zhifen YANG ; Xueling ZHANG ; Xia LI ; Junna ZHANG
Publication Type:Journal Article
Keywords: Heat shock protein-90; Hypertensive disorders complicating pregnancy; Placenta
From: Clinical Medicine of China 2013;29(z1):83-85
CountryChina
Language:Chinese
Abstract: Objective To detect heat shock protein 90 (HSP90) expression in the placenta in pregnancy induced hypertension in order to understand its role in the pathophysiology of hypertensive disorders comphcating pregnancy (HDCP).Methods The gene and protein expression of HSP90 in the placenta of normal pregnant women,gestational hypertension patients,mild preeclampsia patients,severe preeclampsia patients,by RT-PCR and Western blotting.Results The gene and protein expression of HSP90 in placenta of gestational hypertension group,mild preeclampsia group,severe preeclampsia group were significantly higher than that of normal pregnant group (P ＜ 0.01),and it showed the increased progressively with the increasing of disease stage.Conclusion HSP90 may be involved in the onset and development of HDCP.Monitoring HSP90 concentration in the placenta which is the initial theoretical basis for the target as HSP90 for the treatment of HDCP.