Effect of the down regulation of p120-catenin on the proliferation and invasion of human bladder carcinoma cell line T24 in Vitro
10.3760/cma.j.issn.1008-6315.2013.13.008
- VernacularTitle:p120-catenin表达下调对T24细胞增殖及侵袭能力的影响
- Author:
Kai LIANG
;
Dexiang LU
;
Dapeng SUN
- Publication Type:Journal Article
- Keywords:
p120ctn;
T24 cells;
Proliferation;
Invasion
- From:
Clinical Medicine of China
2013;29(z1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the regulating function of p120-catenin (p120ctn) on proliferation and invasion of human bladder cancer cell T24.Methods Special siRNA was used to silence the expression of p120ctn in T24 cells.MTT assay was used to examine the T24 cell growth rate.The invasion of T24 cells and the control cells were measured by transwell chamber assay.Results The silencing of p120ctn could improve the proliferation and the invasiveness of T24 tumor cells.Transwell chamber assay showed that the in vitro invasion function of T24 cells was significant increase after p120ctn-siRNA.Conclusion p120ctn inhibited the bladder cancer proliferation and invasiveness of bladder carcinoma cells.
