Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by beta-adrenoceptor.
10.5625/lar.2011.27.4.317
- Author:
Mehari ENDALE
1
;
Jae Chan SONG
;
Man Hee RHEE
;
Kwang Hyeon LIU
;
Taek Kyum KIM
;
Joong Goo KWON
;
Kyung Sik PARK
;
Ki Myung CHUNG
;
Tae Wan KIM
Author Information
1. College of Veterinary Medicine, Kyungpook National University, Daegu, Korea. twkim@mail.knu.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
Suaeda asparagoides;
gastric antrum;
spontaneous contraction;
beta-adrenoceptor;
SERCA
- MeSH:
Animals;
Baths;
Calcium-Transporting ATPases;
Carbamates;
Chenopodiaceae;
Contracts;
Gastrointestinal Diseases;
Gastrointestinal Motility;
Herbal Medicine;
Indoles;
Muscle, Smooth;
Muscles;
Organometallic Compounds;
Orientation;
Oxadiazoles;
Phentolamine;
Propranolol;
Pyloric Antrum;
Quinoxalines;
Rats;
Ryanodine;
Sarcoplasmic Reticulum;
Tetrodotoxin;
Water
- From:Laboratory Animal Research
2011;27(4):317-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are scarce. The present study investigated the effects of Suaeda asparagoides water fraction of the extract (SAWF) on antral motility in vitro. Muscle strips from rat gastric antrum were set up in an organ bath in a circular orientation. SAWF (100 microg/mL) inhibited the spontaneous contraction of antral circular muscle strips. These inhibitory effects were not significantly affected by tetrodotoxin (1 microM), N omega-Nitro-L-arginine methyl ester hydrochloride (100 microM), 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one (10 microM), ryanodine (10 microM) and phentolamine (10 microM). SAWF-induced inhibition was mostly restored by cyclopiazonic acid (10 microM). Furthermore, the beta-adrenergic receptor antagonist, propranolol (10 microM), abolished SAWF-induced inhibition. These results suggest that SAWF may exert its activity on gastrointestinal smooth muscle via a-adrenergic receptors and sarcoplasmic reticulum Ca2+ ATPase.
