A clinical study on ten-day sequential therapy for H.pylori eradication
10.3760/cma.j.issn.1008-6706.2014.13.013
- VernacularTitle:十天序贯疗法根除幽门螺杆菌的临床研究
- Author:
Hanbo YU
;
Wenjing CHEN
;
Huanchun WU
;
Qisheng ZHOU
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Drug therapy,combination;
Oral,sequential
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(13):1951-1953
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effect of ten-day sequential therapy composed of omeprazole,amoxicillin,clarithromycin,levofloxacin in Helicobacter pylori (Hp) eradication.Methods 120 adult patients with positive rapid urease test of gastric mucosa were selected,they were randomly divided into the sequential group (60 cases) and control group (60 cases).The sequential group was treated with 10 d sequential therapy and control group was given 10 d standard therapy for eradication of Hp.In the two groups,patients with active ulcerative continued taking omeprazole for 4 weeks,the 14C urea breath test was taken after stopping drug,negative for Hp eradication.The clinical efficacy of two groups was observed.Results Hp eradication rate of sequential group was 94.8 ％,which was significantly higher than 79.3 ％ of the control group (x2 =6.20,P ＜ 0.05).The incidence rate of adverse reactions in the sequential group was 17.5％,which in control group was 15.0％,the difference was not significant (x2 =0.06,P ＞ 0.05).Conclusion Ten-day sequential therapy composed of omeprazole,amoxicillin,clarithromycin,levofloxacin for eradication of Hp is safe,the cure rate is high,and the adverse reaction is similar with standard therapy,it is worth the clinical promotion.
