Change and significance of CD4+CD25+ regulatory T cells in patients with autoimmune hemolytic anemia
10.3760/cma.j.issn.1008-6706.2014.13.012
- VernacularTitle:CD4+CD25+调节性T细胞在自身免疫性溶血性贫血患者中的变化及意义
- Author:
Dongping HUANG
;
Hesheng HE
- Publication Type:Journal Article
- Keywords:
T-lymphocytes,regulatory;
Anemia,hemolytic,autoimmune
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(13):1949-1951
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of regulatory T-cells (Treg) before and after therapy in patients with autoimmune hemolytic anemia (AIHA),and to study the role of Treg in AIHA.Methods Treg cells numbers was measured by flow cytometry.Results Before treatment,Treg cells in AIHA patients was (1.32 ± 0.87) ％,which was significantly lower than (3.08 ± 0.96) ％ in the controls (t =-5.37,P ＜ 0.01).After treatment,Treg cells in AIHA patients was significantly increased [(4.96 ± 1.13)％] (t =-16.94,P ＜0.01).Conclusion Treg cells decreased in AIHA patients.Glucocorticoid might play a role in AIHA treatment by up-regulating Treg cells number.
