Clinical study of thermotherapy with chemotherapy in advanced non-small cell lung cancer with neuroendocrine differentiation
10.3760/cma.j.issn.1008-6706.2014.12.012
- VernacularTitle:热疗联合化疗治疗晚期非小细胞肺癌伴神经内分泌化的临床研究
- Author:
Yong WANG
;
Yanshun ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Neuroendocrine differentiation;
Thermotherapy;
Drug therapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(12):1787-1788
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of thermotherapy combined chemotherapy in the treatment of the advanced non-small cell lung carcinoma with neuroendocrine differentiation (NSCLC-NED).Methods The clinical data of 16 patients with NSCLC-NED were retrospectively reviewed.To analyzed the efficacy and survival of these patients.All patients were treated by thermotherapy with the combined chemotherapy regiment of platinum agents.Results There were 7 partial responses and 4 stable disease,The overall response rate (RR) was 43.8％.The one year survival rate was 37.5％ (6/16).The improvement rate of quality of life was 62.5％ (10/16).Conclusion Neuroendocrine differentiation is an important indicator of biological behavior of NSCLC.Thermochemotherapy is an active regimen in the advanced NSCLC-NED with an acceptabe toxicity.
