Relationship of the levels of serum ET-1, MCP-1 and MMP-9 in coronary heart disease
10.3760/cma.j.issn.1008-6706.2014.12.011
- VernacularTitle:血清内皮素、单核细胞趋化蛋白和基质金属蛋白酶-9水平与冠心病的关系研究
- Author:
Baiyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia;
Endothelin-1;
Monocyte chemoattractant proteins;
Matrix metalloproteinases
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(12):1785-1786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship of the levels of serum ET-1,MCP-1 and MMP-9 in patients with different type coronary heart disease (CHD).Methods 80 CHD patients were divided into 3 groups,including 22 cases of acute myocardial infarction (AMI),33 cases of unstable angina (UAP),25 cases of stable angina (SAP) and control group consisted of 30 healthy people.The levels of ET-1,MCP-1 and MMP-9 were measured by enzymelinked immunosorbent assay (ELISA).The levels of serum ET-1,MCP-1 and MMP-9 in different groups were compared.Results The serum levels of ET-1,MCP-1 and MMP-9 in AMI,UAP and SAP groups were significantly higher than those in the control group (t =5.12,5.35,5.15,4.22,4.65,4.54,3.12,3.65,3.54,all P ＜ 0.05).Compared with SAP group,the levels of ET-1,MCP-1 and MMP-9 were increased in AMI and UAP groups (t =4.32,4.15,4.52,3.54,3.23,3.51,all P ＜ 0.05).Compared with UAP group,the levels of ET-1,MCP-1 and MMP-9 were increased in AMI groups (t =3.78,3.96,3.56,all P ＜ 0.05).Conclusion Serum ET-1,MCP-1 and MMP-9 may be the markers of coronary atherosclerosis and involved in the process of CHD.The levels of serum ET-1,MCP-1 and MMP-9 are correlated with the severity of CHD.
