Correlation analysis of renal function and serum cystatin C in patients with kidney damage secondary to cirrhosis
10.3760/cma.j.issn.1008-6706.2014.11.034
- VernacularTitle:肝硬化并发肾功能损害患者血清胱抑素C与肾功能指标相关性分析
- Author:
Fang ZHAO
;
Yongsheng NIU
;
Dongsheng ZHANG
;
Jianjing SHANG
- Publication Type:Journal Article
- Keywords:
Glomerular filtration rate;
Cystatin C;
Liver cirrhosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(11):1678-1680
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum cystatin C(Cys-C)and renal function in patients with renal damage secondary to cirrhosis.Methods 129 patients with liver cirrhosis were selected,according to the measured glomerular filtration rate (GFR) as the gold standard for evaluation of renal function,patients were divided into group A(cirrhosis with normal renal function),group B(cirrhosis following renal insufficiency),group C (cirrhosis secondary to renal failure).The concentration of Cys-C was compared among three groups,and the serum creatinine(Scr),serum proteins ball micro β2 (β2-MG),creatinine clearance (Ccr) were detected.Results Cys-C,Scr,β2-MG,Ccr and other indicators of A,B,C three groups increased or decreased with the severity of impaired renal function(t =6.65,6.85,6.58,4.54,all P ＜ 0.05).The abnormal detection rates of Cys-C,Scr,Ccr,β2-MG in A group were 31.1％,11.1％,8.9％,26,7％,those in B group were 83.7％,30.2 ％,34.9％,46.5％,those in C group were 100.0％,85.4％,87.8％,95.1％.Conclusion Serum Cys-C concentration is a sensitive marker to evaluate glomerular filtration,it has accurate and reliable clinical significance in the early diagnosis of liver cirrhosis secondary to kidney damage.
