Observation of the effect of alprostadil combined with valsartan in the treatment of chronic glomerulonephritis proteinuria
10.3760/cma.j.issn.1008-6706.2014.11.033
- VernacularTitle:前列地尔联合缬沙坦治疗慢性肾小球肾炎蛋白尿的疗效观察
- Author:
Xiaoyan XUAN
;
Aicheng YANG
;
Zian LIANG
;
Jiefeng LI
;
Baoan WANG
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Proteinuria;
Alprostadil;
Valsartan
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(11):1676-1677
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of alprostadil combined with valsartan in treatment of chronic glomerulonephritis proteinuria.Methods 78 patients with chronic glomerulonephritis proteinuria were randomly divided into two groups,and each group had 39 cases.The control group was given conventional treatment,while the observation group was given alprostadil combined with valsartan on the basis of the control group.The clinical outcomes were compared between the two groups.Results The total effective rate of the observation group was 92.31％,which was significantly higher than 74.36％ of the control group (x2 =9.825,P ＜ 0.05).After treatment,the 24h Upro,BUN and SCr of the observation group were (1.00 ± 0.39) g/24h,(7.11 ± 0.15) mmol/L and (80.86 ± 0.65) μmol/L,which were significantly lower than those of the control group [(1.30 ± 0.48) g/24h、(9.18 ± 2.21) mmol/L and (98.71 ± 4.34) μmol/L],the differences were statistically significant (t =9.32,7.83,7.12,all P ＜ 0.05).Conclusion Alprostadil combined with valsartan in the treatment of chronic glomerulonephritis proteinuria has significant effect,and it can significantly alleviate clinical symptoms,improve renal function,which should be widely applied in clinical.
