Observation of the effects of 5-aminolevulinic acid photodynamic therapy combined with fulguration in treating perianal condyloma
10.3760/cma.j.issn.1008-6706.2014.11.006
- VernacularTitle:5-氨基酮戊酸光动力疗法联合电灼术治疗肛周尖锐湿疣疗效观察
- Author:
Huahong WU
;
Songbo CHEN
;
Jinnan CAI
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
5-aminolevulinic acid;
Photodynamic therapy;
Fulguration
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(11):1612-1614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relapse rate and the effect of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) combined with fulguration in the treatment of perianal genital warts.Methods 67 patients with perianal genital warts were randomly divided into the three groups.22 cases in the fulguration and ALA-PDT treatment group performed the ALA-PDT treatment immediately after removal of dominant wart by fulguration,once a week,treatment for 3-4 times.22 cases in the ALA-PDT treatment group only underwent ALA-PDT treatment,once a week,treatment for one month.23 cases in the fulguration group were given the traditional fulguration methods one by one electrocautery fulguration gasification treatment for all skin lesions,a weekly batch treatment,treatment for a month.Follow-up six months after the last treatment to determine efficacy and recurrence rate.Results The cure rate of combined treatment group was 90.9％ (20/22),and recurrence rate was 9.1％ (2/22) ;cure rate of photodynamic group was 54.5％ (12/22),and its recurrence rate was 22.7％ (5/22) ; cure rate of fulguration group was 39.1％ (9/23),and the recurrence rate was 43.5％ (10/23).There were statistically significant differences in the cure rate and relapse rate between combination therapy group and electrocautery treatment group (P =0.000,P =0.017).Conclusion The fulguration combined with ALA-PDT in the treatment of perianal genital warts has high cure rate,low recurrence rate,and less side effects.
