Expression of SGK in uterine decidua of patients with unexplained recurrent spontaneous abortion

VernacularTitle:分子开关蛋白激酶在不明原因复发性流产患者蜕膜组织中的表达
Author: Qing BAO ; Yong ZHAO ; Junqin YAN ; Wensong LIN ; Wei LIU
Publication Type:Journal Article
Keywords: Protein kinases; Abortion,habitual; Decidua; Apoptosis
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(13):1947-1949
CountryChina
Language:Chinese
Abstract: Objective To observe the expression of SGK in decidua in patients with unexplained recurrent spontaneous abortion(URSA) and to investigate its role in the course of apoptosis.Methods The expression of SGK was detected by immunohistochemistry in decidua of URSA(abortion group,n =50) and normal first trimester pregnant women(control group,n =30).The apoptotic index was detected by TUNEL.Results Compared with the control group,the positive expression of SGK decreased significantly in the abortion group,and the difference was statistically significant(x2 =6.78,P ＜ 0.05).The average apoptotic index of the abortion group was (8.19 ± 3.58) ％,which was significantly higher than (2.87 ±1.07)％ of the control group(t =7.94,P＜0.05).Conclusion Intensive apoptosis,the decreasing positive expression rate of SGK in decidua cells may play critical roles in URSA.