Relationship between hOGG1 and XPD gene polymorphism and genetic susceptibility of gastric cancer
10.3760/cma.j.issn.1008-6706.2014.13.006
- VernacularTitle:人类8-羟基鸟嘌呤DNA糖苷酶1及着色性干皮病基因D基因多态性与胃癌遗传易感性的关系研究
- Author:
Yan GUO
- Publication Type:Journal Article
- Keywords:
DNA glycosylases;
Xeroderma pigmentosum group D protein;
Genetic pleiotropy;
Stomach neoplasms;
Genetic predisposition to disease
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(13):1933-1935
- CountryChina
- Language:Chinese
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Abstract:
Objective To investigate the relationship between hOGG1 and XPD gene polymorphism and genetic susceptibility of gastric cancer.Methods This study was carried out in Dongying Shengli Petroleum Administration Bureau Hospital.Under the narrow band imaging(NBI) mode,the blood samples of a total of 98 gastric cancers and 80 controls without cancers were collected.Genetic polymorphisms of DNA repair genes were identified by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP),then its relationship with cancers was analyzed.Results Carrying 326Cys allele with the wine increased the risk of gastric cancer; Lys 751Gln genotype increased the susceptibility of the gastric cancers (OR =1.486,0.73 ～ 3.025).Conclusion Lys751 Gln genotype increases the risk of gastric cancer.
