The clinical effect of simvastatin combined with ferulate in treatment of early diabetic nephropathy
10.3760/cma.j.issn.1008-6706.2014.12.029
- VernacularTitle:辛伐他汀联合阿魏酸钠治疗早期糖尿病肾病的疗效观察
- Author:
Zelin ZHU
;
Pingxia WANG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Simvastatin;
Ferulate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(12):1827-1828
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of simvastatin combined with ferulate in treatment of early diabetic nephropathy (DN).Methods 106 patients with DN were randomly divided into two groups by random number table,and each group had 53 cases.The control group was given simvastatin,while the observation group was given simvastatin combined with ferulate,and the clinical outcomes were compared between the two groups.Results The total effective rate of the observation group was 92.45％,which was significantly higher than 73.58％ of the control group(x2 =8.992,P ＜ 0.05) ; after treatment,the Upro,SCr,BUN and CRP levels of the observation group were (50.72 ± 7.74) mg/24h,(70.01 ± 8.56) μmol/L,(3.87 ± 0.54) mmol/L and (3.51 ± 0.63) mmol/L,which were significantly lower than (83.74 ± 7.92) mg/24h,(84.33 ± 9.01) μmol/L,(5.03 ± 0.62) mmol/L and (5.52 ± 0.61) mmol/L of the control group,the difference was statistically significant (t =7.73,6.59,8.62,9.30,all P ＜ 0.05).Conclusion Simvastatin combined with ferulate in treatment of early diabetic nephropathy (DN) has significant effect,and it can effectively improve the clinical symptoms and protect renal function,and it has better clinical value.
