Analysis of influence factors of prognosis in patients with endometrial carcinoma receiving neoadjuvant chemotherapy
10.3760/cma.j.issn.1008-6706.2014.11.016
- VernacularTitle:子宫内膜癌患者新辅助化疗的预后影响因素分析
- Author:
Qin ZHANG
;
Junfang WANG
;
Lijuan CHENG
- Publication Type:Journal Article
- Keywords:
Antineoplastic combined chemotherapy protocols;
Endometrial neoplasms;
Factors analysis,statistical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(11):1635-1637
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of pre-chemotherapy hemoglobin and platelet levels on the effect of chemotherapy and prognostic outcome in patients with endometrial carcinoma (EC).Methods 104 patients with EC who underwent surgical treatment following neoadjuvant chemotherapy were retrospectively analyzed.Multiple logistic regression was carried out to evaluate the relationship between the probability of achieving an optimal clinical response and the variables.The log-rank test was used to compare the homogeneity of progression-free survival and overall survival functions across strata defined by categories of prognostic variables.Results The Cox proportional hazard model was used to assess the significance of potential prognostic factors for progression-free survival and overall survival.Multivariate logistic regression analysis indicated that FIGO staging (OR =3.234,95 ％ CI:1.324-13.454) and lymph node metastasis (OR =8.235,95 ％ CI:1.563-18.574) were independent factors of influencing effects of new adjuvant chemotherapy in the treatment of EC patients.Multivariate Cox regression model analysis showed that the FIGO staging(HR =4.342,95％ CI:1.643-15.856) and lymph node metastasis (HR =3.853,95％ CI:1.864-9.675) were independent factors of influencing 5 years survival rate of EC patients received new adjuvant chemotherapy.Conclusion The curative effect and prognosis after receiving neoadjuvant chemotherapy operation in treatment of EC patients before chemotherapy,there was no significant correlation between hemoglobin and platelet levels,and lymph node metastasis,FIGO stage.
