Effect of metformin on serum thyrotropin level in type 2 diabetic patients with subclinical hypothyroidism
10.3760/cma.j.issn.1008-6706.2014.11.009
- VernacularTitle:二甲双胍对2型糖尿病合并原发性亚临床甲状腺功能减退患者血促甲状腺激素水平的影响
- Author:
Jiping NAN
;
Fei GAO
;
Qishan XU
;
Zhanguo ZHAO
;
Jin DONG
- Publication Type:Journal Article
- Keywords:
Metformin;
Subclinical hypothyroidism;
Diabetes mellitus,type 2;
Thyrotropin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(11):1619-1621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of metformin on serum thyrotropin (TSH) level in diabetic patients with subclinical hypothyroidism (SCH).Methods The long-term effects of metformin on thyroid axis hormones were assessed in 55 diabetic patients with primary SCH who were untreated with L-T4(study group),as well as in 31 diabetic patients with normal thyroid function (control group).According to using metformin or not,patients of study group were divided into the metformin group (group 1,n =28),and the non-metformin group(group 2,n =27).Serum TSH levels were compared between baseline and follow-up in patients receiving metformin treatment.Results After 30 weeks of metformin administration,a significant TSH decrease(t =2.91,P ＜ 0.05) was observed in group 1 [from(6.98 ± 1.92) to(2.44 ± 0.61) mIU/L].After stopping metformin therapy,the level of TSH at 52 weeks fol low-up was back to the baseline level [(6.99 ± 1.76) mIU/L,P ＞ 0.05].There was no significant difference in TSH level between baseline and after 30 weeks follow-up in group 2[(6.01 ± 1.63) mIU/L vs(6.21 ± 1.71) mIU/L,P ＞0.05].At the end of 30 weeks follow-up,no significant differences were found in body mass index and thyroid func tion in both metformin group and non-metformin group.In control group,metformin administration for 30 weeks had no effect on TSH level(P ＞ 0.05).Conclusion Metformin administration influences TSH without change of FT4 level in type 2 diabetic patients with primary SCH.
