Effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock

VernacularTitle:黄芩苷对创伤性休克患者血清炎性因子和氧自由基代谢的影响
Author: Junda LIU ; Zhen LAI ; Kewei ZHENG
Publication Type:Journal Article
Keywords: Baicalin; Shock,traumatic; Oxygen free radical; Cytokine
From: Chinese Journal of Primary Medicine and Pharmacy 2014;21(11):1617-1618
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of baicalin on inflammatory factors and oxygen free radical metabolism in patients with traumatic shock.Methods 38 patients with traumatic shock were treated with baicalin 200mg intravenous injection when admitted to hospital.Before and 1 h after treatment,TNF-α,IL-6,IL-8,MDA and SOD were measured in blood.Results Compared with before treatment,TNF-,IL-6,IL-8,and MDA levels were decreased after treatment (t =7.32,6.12,20.21,16.10,all P ＜ 0.05),while SOD activity was significantly increased (t =1.69,P ＜ 0.01).Conclusion Baicalin could inhibit the production and release of inflammatory factors TNF-α,IL-6,IL-8 in patients with traumatic shock,reduce the damage of oxygen free radicals to the cells.Early treatment with baicalin had protective effect on patients with traumatic shock.