Antifibrotic activity a fermentation filtrate of Ganoderma lucidum.
10.5625/lar.2011.27.4.369
- Author:
Sang Chul KWON
1
;
Yun Bae KIM
Author Information
1. Food Safety Support Organization, Korea Food Industry Association, Seoul, Korea.
- Publication Type:Letter
- Keywords:
Carbon tetrachloride (CCl4);
hepatic fibrosis;
Ganoderma lucidum;
fermentation filtrate
- MeSH:
Animals;
Body Weight;
Carbon Tetrachloride;
Fermentation;
Fibrosis;
Ganoderma;
Humans;
Hydroxyproline;
Liver;
Male;
Rats;
Rats, Sprague-Dawley;
Reishi;
Weights and Measures;
Zea mays
- From:Laboratory Animal Research
2011;27(4):369-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl4)-induced hepatic fibrosis were investigated in rats. Male Sprague-Dawley rats were orally administered with FGL (20 or 100 mg/kg) for 33 days, and orally administered with CCl4 (1.0 mL/kg; 2 mL/kg of 50% in corn oil) at 3-day intervals 1 h after FGL treatment. Body and liver weights, blood and histopathological findings in accordance with hydroxyproline concentrations were analyzed. Chronic exposure to CCl4 reduced the body weight gain, but increased liver weights and fibrosis, resulting in 3.35-fold increase in hydroxyproline level. Although FGL did not significantly reduce the CCl4-induced body and liver weight changes, it attenuated the increases in the hepatic fibrosis and hydroxyproline contents. Taken together, it is suggested that FGL might prevent hepatic fibrosis, and that FGL or its ingredient could be a potential candidate for the prevention of chronic hepatic disorders.
