Expression and clinical significance of Rho GDP dissociation inhibitor 2 in pancreatic cancer
10.3760/cma.j.issn.1674-1935.2014.03.008
- VernacularTitle:Rho-GDI2在胰腺癌中的表达及其临床意义
- Author:
Bin YI
;
Yi ZHANG
;
Jian ZHOU
;
Shiduo SONG
;
Xin ZHAO
;
Dechun LI
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Rho-GDP dissociation inhibitor 2;
Pathology,clinical;
RTPCR;
Immunohistochemistry
- From:
Chinese Journal of Pancreatology
2014;14(3):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of Rho GDP dissociation inhibitor 2 (Rho-GDI2) in pancreatic cancer.Methods Immunohistochemistry and RT-PCR were used to evaluate the expression of Rho-GDI2 in 60 pairs of pancreatic cancer tissues and adjacent pancreatic tissues,and its correlation with clinicopathological parameter of pancreatic cancer was also analyzed.Results The expressions of Rho-GDI2 mRNA were 0.661 ± 0.021 and 0.199 ± 0.023 in pancreatic cancer tissues and adjacent pancreatic tissues,and the positive rate of Rho-GDI2 protein expression were 73.3％ (44/60) and 41.7％ (25/60),the positive rate of Rho-GDI2 expression in pancreatic cancer tissues was higher than that of adjacent normal tissues,and the difference between the two groups was statistically significant (P ＜ 0.01).The expression of Rho-GDI2 was strongly correlated with tumor size,differentiation,staging,lymph node metastasis,vascular invasion (P＜0.05),but it was not associated with gender,age,tumor location (P ＞0.05).Conclusions Rho-GDI2 expression is up-regulated in pancreatic cancer,and is strongly correlated with the malignant biological behavior of pancreatic cancer.
