The expression of clusterin and P-glycoprotein in hepatic cell carcinoma and its relationship

VernacularTitle:聚集素、P-糖蛋白在原发性肝细胞癌中的表达及其相关性研究
Author: Fuyong QIAN ; Maoming XIONG ; Hongchun LI
Publication Type:Journal Article
Keywords: Carcinoma,hepatocellular; Immunohistochemistry; Clusterin; P-glycoprotein
From: Chinese Journal of Postgraduates of Medicine 2014;37(17):59-61
CountryChina
Language:Chinese
Abstract: Objective To study the expression of clusterin (CLU) and P-glycoprotein (P-gp) in hepatic cell carcinoma (HCC) and its relationship.Methods The expression of CLU gene in the tissue of H CC (41 cases),cirrhosis(10 cases) and normal liver (10 cases) and the expression of P-gp in the tissue of HCC were detected by immunohistochemical method.Results The positive expression rate of CLU was 82.93％(34/41) in HCC,and negative or weak positive were detected in cirrhosis and normal liver tissue.The positive expression rate of CLU was significantly correlated with Edmondson's histological grade (P ＜ 0.05),but had no correlation with patients' age,sex and cirrhosis (P ＞ 0.05).The positive expression rate of P-gp in HCC was 70.73％(29/41).There was significant correlation between the expression of CLU and P-gp (P ＜ 0.05).Conclusions The over expression of CLU is significantly associated with clinical multidrug resistance in HCC.It should be a potential target for treatment of HCC.